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Home > Research Area > Neuroscience > Fibromyalgia / Chronic Widespread Pain

Fibromyalgia / Chronic Widespread Pain Research Reagents

Fibromyalgia is a chronic widespread pain disorder affecting 2–4% of the population, characterized by central sensitization, altered pain processing, and associated symptoms including fatigue, sleep disturbance, and cognitive dysfunction. Pathophysiology involves elevated CSF substance P, reduced descending serotonergic/noradrenergic inhibition, small fiber neuropathy, and neuroinflammation. Biomarker development remains a critical unmet need for diagnosis and treatment stratification.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

Fibromyalgia / Chronic Widespread Pain Research Reagents - key pathogenic pathways and research targets

Fig. 1 Key pathogenic pathways and research targets. abinScience product targets highlighted in orange.

abinScience provides validated antibodies, recombinant proteins, and ELISA kits for key fibromyalgia and chronic pain research targets. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom antibody development.

Key Research Targets

Substance P (TAC1) — CSF substance P levels are consistently elevated in fibromyalgia, reflecting augmented nociceptive signaling. Anti-substance P antibodies and recombinant proteins support central sensitization research and pain biomarker assay development.
→ Browse Substance P antibodies & proteins

NGF (Nerve Growth Factor) — NGF drives peripheral nociceptor sensitization and small fiber pathology in fibromyalgia. Anti-NGF antibodies (tanezumab, fasinumab class) and recombinant NGF proteins support pain mechanism studies.
→ Browse NGF antibodies & proteins

IL-6 / TNF-α — Elevated serum IL-6 and TNF-α are reported in fibromyalgia, linking systemic inflammation to central sensitization. Cytokine antibodies and ELISA kits support inflammatory profiling and treatment response monitoring.
→ Browse cytokine antibodies & ELISA kits

References

1. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547-1555. DOI

2. Russell IJ, et al. Elevated cerebrospinal fluid levels of substance P in patients with fibromyalgia syndrome. Arthritis Rheum. 1994;37(11):1593-1601. DOI

3. Üçeyler N, et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136(6):1857-1867. DOI

15 product results for "Fibromyalgia / Chronic Widespread Pain"

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  • Human HTR2A Recombinant Protein (N-His) (HB201012)
    abinScience
    Human HTR2A Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    P28223

    Protein length

    [Asp2-Asn75] & [Phe255-Val324]

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Homo sapiens (Human)

    Price(USD): $211.00-$1,627.00
    Cat No. HB201012

  • Human COMT Recombinant Protein (N-His) (HB153012)
    abinScience
    Human COMT Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    P21964

    Protein length

    Gly52-Pro271

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Homo sapiens (Human)

    Price(USD): $211.00-$1,627.00
    Cat No. HB153012

  • Anti-Human BDNF Recombinant Antibody (SAA0471), PE (HB935127)
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    Species reactivity

    Human

    Applications

    ELISA, FCM

    Host species

    Mouse

    Clonality

    Monoclonal

    Isotype

    IgG2a, lambda

    Clone ID

    SAA0471

    Conjugation

    PE

    Price(USD): $256.00-$424.00
    Cat No. HB935127

  • Anti-Human BDNF Recombinant Antibody (SAA0471), PerCP (HB935147)
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    Species reactivity

    Human

    Applications

    ELISA, FCM

    Host species

    Mouse

    Clonality

    Monoclonal

    Isotype

    IgG2a, lambda

    Clone ID

    SAA0471

    Conjugation

    PerCP

    Price(USD): $236.00-$392.00
    Cat No. HB935147

  • Anti-Human BDNF Recombinant Antibody (SAA0471), APC (HB935137)
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    Species reactivity

    Human

    Applications

    ELISA, FCM

    Host species

    Mouse

    Clonality

    Monoclonal

    Isotype

    IgG2a, lambda

    Clone ID

    SAA0471

    Conjugation

    APC

    Price(USD): $256.00-$424.00
    Cat No. HB935137

  • Anti-Human BDNF Recombinant Antibody (SAA0471), FITC (HB935117)
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    Species reactivity

    Human

    Applications

    ELISA, FCM

    Host species

    Mouse

    Clonality

    Monoclonal

    Isotype

    IgG2a, lambda

    Clone ID

    SAA0471

    Conjugation

    FITC

    Price(USD): $196.00-$324.00
    Cat No. HB935117

  • Anti-Human BDNF Recombinant Antibody (SAA0471) (HB935107)
    Anti-Human BDNF Recombinant Antibody (SAA0471)
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    Species reactivity

    Human

    Applications

    ELISA, FCM

    Host species

    Mouse

    Clonality

    Monoclonal

    Isotype

    IgG2a, lambda

    Clone ID

    SAA0471

    Price(USD): $196.00-$326.00
    Cat No. HB935107

  • Human BDNF Recombinant Protein (N-His) (HB935022)
    Human BDNF Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    P23560

    Protein length

    His129-Arg247

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Homo sapiens (Human)

    Price(USD): $211.00-$1,627.00
    Cat No. HB935022

  • BDNF Recombinant Protein (N-His) (MB935012)
    BDNF Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    P23560,P21237,P23363,Q7YRB4,Q0EAB7,Q95106,P14082

    Protein length

    P23560[His129-Arg247], P21237[His131-Arg249], P23363[His131-Arg249], Q7YRB4[His129-Arg247], Q0EAB7[His129-Arg247], Q95106[His132-Arg250], P14082[His134-Arg252]

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Homo sapiens (Human), Mus musculus (Mouse), Rattus norvegicus (Rat), Canis lupus familiaris (Dog) (Canis familiaris), Equus caballus (Horse), Bos taurus (Bovine), Sus scrofa (Pig)

    Price(USD): $211.00-$1,627.00
    Cat No. MB935012

  • Human BDNF Recombinant Protein (C-His) (HB935011)
    Human BDNF Recombinant Protein (C-His)
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    Expression system

    Insect cells

    Accession

    P23560

    Protein length

    His129-Arg247

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Homo sapiens (Human)

    Price(USD): $298.00-$2,878.00
    Cat No. HB935011

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