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Home > Featured Products > Oncology Research > Head and Neck Squamous Cell Carcinoma

Head and Neck Squamous Cell Carcinoma Research Reagents

HNSCC is strongly associated with HPV infection (oropharyngeal) and tobacco/alcohol exposure (non-HPV). EGFR remains the only approved targeted therapy, while PD-1 checkpoint blockade has become first-line for recurrent/metastatic disease. abinScience provides reagents for EGFR, PD-L1, HPV/p16, TROP2, Nectin-4, and B7-H3. RUO

Key Biomarkers & Targets

EGFR
ErbB1 / HER1
Overexpressed in >90% of HNSCC; cetuximab target. 180+ antibodies and biosimilar-grade reference proteins.
Antibodies • Proteins • Biosimilars
PD-1 / PD-L1
CD279 / CD274
Pembrolizumab first-line for PD-L1 CPS ≥1 HNSCC. 260+ combined checkpoint antibodies and proteins.
Antibodies • Proteins • Biosimilars
HPV / p16
HPV-Driven Oropharyngeal
HPV-positive HNSCC has distinct biology and better prognosis. p16 IHC is the clinical surrogate for HPV status. 190+ combined products.
Antibodies • Proteins
TROP2 / Nectin-4
ADC Targets
Emerging ADC targets in HNSCC following success in other epithelial cancers. 50+ combined antibodies and biosimilar proteins.
Antibodies • Proteins • Biosimilars
B7-H3 / CD276
Immune Checkpoint
Overexpressed in HNSCC; emerging target for ADCs and checkpoint therapy. 41 antibodies and biosimilar proteins.
Antibodies • Biosimilars
p63 / CK5/14
Squamous Differentiation
Diagnostic IHC markers for confirming squamous cell origin in poorly differentiated head and neck tumors.
Antibodies

Why Researchers Choose abinScience for HNSCC

EGFR & Cetuximab ComparabilityAnti-EGFR antibodies and biosimilar-grade cetuximab reference proteins for binding, ADCC, and potency testing in HNSCC-derived models.
HPV Status AssessmentHPV L1/E6/E7 antibodies and p16/CDKN2A antibodies for IHC-based HPV status determination in oropharyngeal cancer specimens.
Next-Gen ADC TargetsTROP2, Nectin-4, and B7-H3/CD276 reagents for emerging ADC and bispecific antibody programs targeting HNSCC.
Original Manufacturer PricingDirect-from-manufacturer pricing with no distributor markup. Bulk and custom conjugation options available.

Common Research Applications

  1. HPV-positive vs. HPV-negative stratification: Apply p16/CDKN2A IHC antibodies as a surrogate for HPV status in oropharyngeal cancer, complemented by HPV E6/E7 antibodies for confirmatory testing.
  2. PD-L1 CPS scoring: Use anti-PD-L1 antibodies for research-use IHC to assess Combined Positive Score (CPS) for immunotherapy eligibility studies in HNSCC cohorts.
  3. EGFR-targeted therapy development: Recombinant EGFR-ECD proteins and biosimilar cetuximab for binding kinetics, epitope mapping, and cell-based ADCC assays in HNSCC cell lines.
  4. Squamous differentiation panel: p63, CK5/6, and CK14 antibodies available for squamous differentiation research. See product pages for validated applications.

Documents & QC Data

Download product datasheets, validation images (WB/IHC/IF/FC), CoA, and application protocols on each product page. All data is lot-specific.

FAQs

Which p16 antibodies work for HPV status IHC?

Anti-p16/CDKN2A antibodies available. See product pages for validated applications. Research use only.

Do you carry EGFR biosimilar reference proteins?

Yes. Research-grade cetuximab and panitumumab biosimilar proteins with ELISA, FACS, and Functional assay validation.

What B7-H3 reagents are available?

Anti-B7-H3/CD276 antibodies and research-grade biosimilar proteins available. See product pages for validated applications.

Do you offer multiplex IHC panels for HNSCC?

We provide individual validated antibodies for PD-L1, CD8, CD68, p16, and EGFR that can be combined in sequential or multiplex IHC workflows. Contact us for panel design guidance.

Can I get custom antibodies for novel targets?

Yes — our parent company AtaGenix provides full custom antibody development from immunogen design through hybridoma production and characterization, including targets not yet in our catalog.

314 product results for "Head and Neck Squamous Cell Carcinoma"

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