Fungal Allergen Research Reagents

Alt a 1 (Alternaria alternata) — The major Alternaria allergen, a unique dimeric protein with no known homologs. Alt a 1 sensitization is recognized by >90% of Alternaria-allergic patients and is a strong independent risk factor for severe asthma, near-fatal asthma episodes, and thunderstorm asthma outbreaks. Recombinant Alt a 1 is the key diagnostic component for Alternaria sensitization.
→ Browse Alt a allergen proteins

Asp f 1 / Asp f 2 / Asp f 3 / Asp f 6 (Aspergillus fumigatus) — Aspergillus allergens define the clinical spectrum from simple sensitization to ABPA. Asp f 1 (ribotoxin) and Asp f 3 (peroxisomal protein) indicate simple Aspergillus sensitization; Asp f 4 and Asp f 6 are secreted allergens associated with ABPA and indicate fungal colonization. This CRD pattern (Asp f 1/3 positive vs Asp f 4/6 positive) differentiates simple sensitization from ABPA, guiding antifungal and corticosteroid therapy decisions.
→ Browse Asp f allergen proteins

Cla h (Cladosporium herbarum) / Pen ch (Penicillium chrysogenum) — Additional outdoor (Cladosporium) and indoor (Penicillium) mold allergens. Cladosporium is the most abundant airborne mold worldwide but less clinically severe than Alternaria. Penicillium sensitization is associated with damp indoor environments and sick building syndrome.
→ Browse Cla h / Pen ch allergen proteins

1. Agarwal R, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850-873. DOI

2. Gabriel MF, et al. Alternaria alternata allergens: markers of exposure, phylogeny and risk of fungal infection. Environ Int. 2016;89-90:71-80. DOI