

| Catalog No. | HC493014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-TFDP1 Polyclonal Antibody (HC493014) is a rabbit polyclonal antibody detecting TFDP1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human TFDP1 (Gly6-Asp410). | ||||||||
| Target | DRTF1-polypeptide 1, DRTF1, E2F dimerization partner 1, TFDP1, DP1, Transcription factor Dp-1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q14186 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Transcription factor Dp-1 (TFDP1) is a ~45 kDa protein. Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. 1. Wu, CL. et al. (1995) Molecular and cellular biology 15, 2536-46. PMID: 7739537 2. Helin, K. et al. (1993) Genes & development 7, 1850-61. PMID: 8405995 3. Zaragoza, K. et al. (2010) Molecular and cellular biology 30, 2293-304. PMID: 20176812 | ||||||||
| Note | For research use only. |
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