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Anti-TRAF4 Polyclonal Antibody (HV470014)

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Overview
Catalog No.HV470014
Description
Anti-TRAF4 Polyclonal Antibody (HV470014) is a rabbit polyclonal antibody detecting TRAF4 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human TRAF4 (Gln193-Asp444).
Target CART1, MLN62, RING finger protein 83, TRAF4, MLN 62, Cysteine-rich domain associated with RING and Traf domains protein 1, RNF83, Metastatic lymph node gene 62 protein, TNF receptor-associated factor 4
Purification Purified by antigen affinity column.
Accession Q9BUZ4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

TNF receptor-associated factor 4 (TRAF4) is a ~53 kDa protein. Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction.

1. Cai, G. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11531-11536. PMID: 30352854
2. Li, J. et al. (2019) Cell death and differentiation 26, 2652-2666. PMID: 31076633
3. Cen, S. et al. (2020) EBioMedicine 54, 102722. PMID: 32268273
4. Yu, W. et al. (2021) The Journal of biological chemistry 296, 100739. PMID: 33991522
5. Yu, X. et al. (2020) Journal of hematology & oncology 13, 40. PMID: 32357935
Note For research use only.
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Datasheet
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Formula
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Anti-TRAF4 Polyclonal Antibody

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