Anti-CD113/NECTIN3 Polyclonal Antibody (HV970014)

Name: Anti-CD113/NECTIN3 Polyclonal Antibody
Brand: abinScience
SKU: HV970014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV970014

Description

Anti-CD113/NECTIN3 Polyclonal Antibody (HV970014) is a rabbit polyclonal antibody detecting NECTIN3 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD113/NECTIN3 (Thr171-Ser356).

Target

CDw113, PRR3, PVRL3, Poliovirus receptor-related protein 3, NECTIN3, Nectin cell adhesion molecule 3, CD113, Nectin-3

Purification

Purified by antigen affinity column.

Accession

Q9NQS3

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Nectin-3 (CD113/NECTIN3) is a ~61 kDa protein. Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses.

1. Fujito, T. et al. (2005) The Journal of cell biology 171, 165-73. PMID: 16216929

Note

For research use only.

Images

References

Datasheet