Anti-MAP2K7 Polyclonal Antibody (HT186014)

Name: Anti-MAP2K7 Polyclonal Antibody
Brand: abinScience
SKU: HT186014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HT186014

Description

Anti-MAP2K7 Polyclonal Antibody (HT186014) is a rabbit polyclonal antibody detecting MAP2K7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MAP2K7 (Thr103-Arg419).

Target

SAPKK4, JNK-activating kinase 2, MAPK/ERK kinase 7, MAPKK 7, c-Jun N-terminal kinase kinase 2, JNKK2, SAPK kinase 4, MEK 7, MAP kinase kinase 7, SKK4, PRKMK7, Dual specificity mitogen-activated protein kinase kinase 7, Stress-activated protein kinase kinase 4, JNK kinase 2, MKK7, MAP2K7, MEK7, JNKK 2, SAPKK-4

Purification

Purified by antigen affinity column.

Accession

O14733

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) is a ~47 kDa protein. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue.

1. Huang, YA. et al. (2017) Cell 168, 427-441.e21. PMID: 28111074

Note

For research use only.

Images

References

Datasheet

Anti-MAP2K7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-MAP2K7 Polyclonal Antibody (HT186014)

Overview

Images

References

Datasheet

SDS

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