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Anti-Rituximab Polyclonal Antibody (AY257024)

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Overview
Catalog No.AY257024
ApplicationsELISA
Host speciesRabbit
IsotypeIgG
ClonalityPolyclonal
ImmunogenRituximab
TargetRabbit polyclonal to Rituxan.
SpecificityThe product is specific for Rituximab. This antibody serves as an excellent positive control for Rituximab immunogenicity (ADA) assays.
PurificationPurified by antigen affinity column.
Accession 174722-31-7
FormLiquid
Storage buffer0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and StorageThe product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.
BackgroundRituximab (Rituxan) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of patients with certain autoimmune diseases and types of cancer, such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, idiopathic thrombocytopenic purpura, and pemphigus vulgaris. Rituximab is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells. When it binds to this protein it triggers cell death.
• Induction Immunosuppression in High-risk Kidney Transplant Recipients., PMID:27041548
• Acute Rejection Following Kidney Transplantation: State-of-the-Art and Future Perspectives., PMID:32520680
• Induction immunosuppressive therapies in renal transplantation., PMID:21258026
• Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production., PMID:18976291
• Removal of therapeutic anti-lymphocyte antibodies from human sera prior to anti-human leukocyte antibody testing., PMID:15896799
• [Biological treatment following renal transplantation]., PMID:21877601
• Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity., PMID:12632061
• Flow cytometric assay detecting cytotoxicity against human endogenous retrovirus antigens expressed on cultured multiple sclerosis cells., PMID:23656307
• Life-threatening hemolytic anemia due to an autoanti-Pr cold agglutinin: evidence that glycophorin A antibodies may induce lipid bilayer exposure and cation permeability independent of agglutination., PMID:19843291
NoteFor research use only.
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