Anti-Human PIEZO1 Polyclonal Antibody (HP708014)

Name: Anti-Human PIEZO1 Polyclonal Antibody
Brand: abinScience
SKU: HP708014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP708014

Description

Anti-Human PIEZO1 Polyclonal Antibody (HP708014) is a rabbit polyclonal antibody detecting PIEZO1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PIEZO1 (Gln2206-Lys2426).

Target

Piezo-type mechanosensitive ion channel component 1, FAM38A, PIEZO1, Protein FAM38A, KIAA0233, Mib, Membrane protein induced by beta-amyloid treatment

Purification

Purified by antigen affinity column.

Accession

Q92508

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is a ~286 kDa protein. Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents.

1. Andolfo, I. et al. (2013) Blood 121, 3925-35, S1-12. PMID: 23479567

2. Albuisson, J. et al. (2013) Nature communications 4, 1884. PMID: 23695678

3. Gnanasambandam, R. et al. (2015) PloS one 10, e0125503. PMID: 25955826

4. Zhou, Z. et al. (2023) Science (New York, N.Y.) 381, 799-804. PMID: 37590348

5. McHugh, BJ. et al. (2010) Journal of cell science 123, 51-61. PMID: 20016066

6. Li, J. et al. (2014) Nature 515, 279-282. PMID: 25119035

7. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007

Note

For research use only.

Images

References

Datasheet

Anti-Human PIEZO1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PIEZO1 Polyclonal Antibody (HP708014)

Overview

Images

References

Datasheet

SDS

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