

| Catalog No. | HX242014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human SRSF2/SC-35 Polyclonal Antibody (HX242014) is a rabbit polyclonal antibody detecting SC-35 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Chicken, and Pan troglodytes.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human SRSF2/SC-35 (Met1-Ser101). | ||||||||
| Target | Splicing factor SC35, Splicing factor, arginine/serine-rich 2, SC-35, Serine/arginine-rich splicing factor 2, SFRS2, SRSF2, Splicing component, 35 kDa, Protein PR264 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q01130 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Serine/arginine-rich splicing factor 2 (SRSF2/SC-35) is a ~25 kDa protein. Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. | ||||||||
| Note | For research use only. |
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