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Anti-Human ADH5 Polyclonal Antibody (HY494014)

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Overview
Catalog No.HY494014
Description
Anti-Human ADH5 Polyclonal Antibody (HY494014) is a rabbit polyclonal antibody detecting ADH5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ADH5 (Met1-Ile374).
Target ADHX, ADH5, FDH, Alcohol dehydrogenase class chi chain, Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase, FALDH, Glutathione-dependent formaldehyde dehydrogenase, Alcohol dehydrogenase 5
Purification Purified by antigen affinity column.
Accession P11766
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Alcohol dehydrogenase class-3 (ADH5) is a ~39 kDa protein. Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation.

1. Engeland, K. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2491-4. PMID: 8460164
2. Collins, XH. et al. (2005) The Journal of biological chemistry 280, 33157-64. PMID: 16081420
3. Oka, Y. et al. (2020) Science advances 6. PMID: 33355142
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ADH5 Polyclonal Antibody

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