Anti-Human MICAL1 Polyclonal Antibody (HP691014)

Name: Anti-Human MICAL1 Polyclonal Antibody
Brand: abinScience
SKU: HP691014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP691014

Description

Anti-Human MICAL1 Polyclonal Antibody (HP691014) is a rabbit polyclonal antibody detecting MICAL1 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MICAL1 (Met1-Lys488).

Target

NICAL, [F-actin]-monooxygenase MICAL1, MICAL1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, Molecule interacting with CasL protein 1, MICAL

Purification

Purified by antigen affinity column.

Accession

Q8TDZ2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

[F-actin]-monooxygenase MICAL1 is a ~117 kDa protein. Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections.

1. Wu, H. et al. (2018) Scientific reports 8, 937. PMID: 29343822

2. Zucchini, D. et al. (2011) Archives of biochemistry and biophysics 515, 1-13. PMID: 21864500

3. Vitali, T. et al. (2016) Archives of biochemistry and biophysics 593, 24-37. PMID: 26845023

4. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433

Note

For research use only.

Images

References

Datasheet

Anti-Human MICAL1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human MICAL1 Polyclonal Antibody (HP691014)

Overview

Images

References

Datasheet

SDS

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