Anti-Human VDAC2 Polyclonal Antibody (HW594014)

Name: Anti-Human VDAC2 Polyclonal Antibody
Brand: abinScience
SKU: HW594014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HW594014

Description

Anti-Human VDAC2 Polyclonal Antibody (HW594014) is a rabbit polyclonal antibody detecting VDAC2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Meleagris gallopavo.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat, Bos taurus, Meleagris gallopavo, Mesocricetus auratus, Oryctolagus cuniculus, Pig, Xenopus laevis

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human VDAC2 (Gly36-Ala294).

Target

Outer mitochondrial membrane protein porin 2, Voltage-dependent anion-selective channel protein 2, VDAC2, hVDAC2, VDAC-2

Purification

Purified by antigen affinity column.

Accession

P45880

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Non-selective voltage-gated ion channel VDAC2 is a ~31 kDa protein. Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials. There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.

1. Blachly-Dyson, E. et al. (1993) The Journal of biological chemistry 268, 1835-41. PMID: 8420959

2. Dadsena, S. et al. (2019) Nature communications 10, 1832. PMID: 31015432

3. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human VDAC2 polyclonal antibody at 1ug/mL on recombinant Human VDAC2 (Catalog No. HW594012).

References

Datasheet

Anti-Human VDAC2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human VDAC2 Polyclonal Antibody (HW594014)

Overview

Images

References

Datasheet

SDS

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