Anti-Human PANX1 Polyclonal Antibody (HP450014)

Name: Anti-Human PANX1 Polyclonal Antibody
Brand: abinScience
SKU: HP450014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HP450014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human PANX1 (Ser236-Gln274).

Target

MRS1, Pannexin-1, PANX1

Purification

Purified by antigen affinity column.

Accession

Q96RD7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Pannexin-1 (PANX1) is a ~48 kDa protein. Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate. Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

1. Bao, L. et al. (2004) FEBS letters 572, 65-8. PMID: 15304325

2. Vanden Abeele, F. et al. (2006) The Journal of cell biology 174, 535-46. PMID: 16908669

3. Bunse, S. et al. (2010) The Journal of biological chemistry 285, 38444-52. PMID: 20829356

4. Chekeni, FB. et al. (2010) Nature 467, 863-7. PMID: 20944749

5. Sang, Q. et al. (2019) Science translational medicine 11. PMID: 30918116

6. Medina, CB. et al. (2020) Nature 580, 130-135. PMID: 32238926

Note

For research use only.

Images

References

Datasheet

Anti-Human PANX1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PANX1 Polyclonal Antibody (HP450014)

Overview

Images

References

Datasheet

SDS

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