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Anti-Human SPTLC2 Polyclonal Antibody (HT093014)

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Overview
Catalog No.HT093014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SPTLC2 (Gly186-Gln536).
Target LCB2a, SPT 2, Serine palmitoyltransferase 2, LCB 2, KIAA0526, Long chain base biosynthesis protein 2, SPTLC2, LCB2, Long chain base biosynthesis protein 2a, Serine-palmitoyl-CoA transferase 2
Purification Purified by antigen affinity column.
Accession O15270
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Serine palmitoyltransferase 2 (SPTLC2) is a ~62 kDa protein. Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA.

1. Han, G. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 8186-91. PMID: 19416851
2. Hornemann, T. et al. (2009) The Journal of biological chemistry 284, 26322-30. PMID: 19648650
3. Gable, K. et al. (2010) The Journal of biological chemistry 285, 22846-52. PMID: 20504773
4. Rotthier, A. et al. (2010) American journal of human genetics 87, 513-22. PMID: 20920666
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human SPTLC2 Polyclonal Antibody

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