Anti-Human DIO2 Polyclonal Antibody (HP806014)

Name: Anti-Human DIO2 Polyclonal Antibody
Brand: abinScience
SKU: HP806014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP806014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DIO2 (Leu69-Leu269).

Target

DIO2, TXDI2, ITDI2, Type II iodothyronine deiodinase, Type-II 5'-deiodinase, Type 2 DI, 5DII, DIOII

Purification

Purified by antigen affinity column.

Accession

Q92813

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Type II iodothyronine deiodinase (DIO2) is a ~30 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine.

1. Curcio-Morelli, C. et al. (2003) Endocrinology 144, 937-46. PMID: 12586771

2. Buettner, C. et al. (2000) Endocrinology 141, 4606-12. PMID: 11108274

3. Salvatore, D. et al. (1999) Biochimie 81, 535-8. PMID: 10403186

4. Piehl, S. et al. (2008) Rapid communications in mass spectrometry : RCM 22, 3286-96. PMID: 18821722

5. Piehl, S. et al. (2008) Endocrinology 149, 3037-45. PMID: 18339710

Note

For research use only.

Images

References

Datasheet

Anti-Human DIO2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human DIO2 Polyclonal Antibody (HP806014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us