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Anti-Human SKIV2L Polyclonal Antibody (HS917014)

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Overview
Catalog No.HS917014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SKIV2L (Gly803-His975).
Target SKIV2L, Helicase SKI2W, W, Helicase-like protein, HLP, SKI2W, Ski2, SKIV2, DDX13
Purification Purified by antigen affinity column.
Accession Q15477
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Superkiller complex protein 2 (SKIV2L) is a ~137 kDa protein. Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.

1. Zhu, B. et al. (2005) Genes & development 19, 1668-73. PMID: 16024656
2. Zinoviev, A. et al. (2020) Molecular cell 77, 1340-1349.e6. PMID: 32006463
3. Kögel, A. et al. (2022) Molecular cell 82, 756-769.e8. PMID: 35120588
4. Nicholson-Shaw, T. et al. (2025) RNA (New York, N.Y.) 31, 1195-1205. PMID: 40441874
Note For research use only.
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Formula
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Anti-Human SKIV2L Polyclonal Antibody

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