Anti-Human GSDME Polyclonal Antibody (HT311014)

Name: Anti-Human GSDME Polyclonal Antibody
Brand: abinScience
SKU: HT311014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT311014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GSDME (Met1-Cys235).

Target

ICERE-1, ICERE1, GSDME-CT, GSDME-NT, DFNA5, Inversely correlated with estrogen receptor expression 1, Gasdermin-E, GSDME, Non-syndromic hearing impairment protein 5

Purification

Purified by antigen affinity column.

Accession

O60443

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gasdermin-E (GSDME) is a ~54 kDa protein. Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.

1. Ding, J. et al. (2016) Nature 535, 111-6. PMID: 27281216

2. Wang, Y. et al. (2017) Nature 547, 99-103. PMID: 28459430

3. Zhou, B. et al. (2021) Cell reports 35, 108998. PMID: 33852854

4. Planès, R. et al. (2022) Molecular cell 82, 2385-2400.e9. PMID: 35594856

5. Ren, Y. et al. (2023) Cancer research 83, 1074-1093. PMID: 36607699

Note

For research use only.

Images

References

Datasheet

Anti-Human GSDME Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human GSDME Polyclonal Antibody (HT311014)

Overview

Images

References

Datasheet

SDS

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