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Anti-Human PPP1R13L Polyclonal Antibody (HP038014)

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Overview
Catalog No.HP038014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PPP1R13L (Asn626-Gly816).
Target IASPP, Inhibitor of ASPP protein, NKIP1, RAI, NFkB-interacting protein 1, PPP1R13BL, RelA-associated inhibitor, Protein iASPP, PPP1R13L, PPP1R13B-like protein
Purification Purified by antigen affinity column.
Accession Q8WUF5
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

RelA-associated inhibitor (PPP1R13L) is a ~89 kDa protein. Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Is involved in NF-kappa-B dependent negative regulation of inflammatory response.

1. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540
2. Falik-Zaccai, TC. et al. (2017) EMBO molecular medicine 9, 319-336. PMID: 28069640
Note For research use only.
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Formula
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Anti-Human PPP1R13L Polyclonal Antibody

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