Anti-Human SNU13 Polyclonal Antibody (HX240014)

Name: Anti-Human SNU13 Polyclonal Antibody
Brand: abinScience
SKU: HX240014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HX240014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SNU13 (Met1-Val128).

Target

High mobility group-like nuclear protein 2 homolog 1, SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein, OTK27, hSNU13, SNU13 homolog, U4/U6.U5 small nuclear ribonucleoprotein SNU13, NHP2-like protein 1, NHP2L1

Purification

Purified by antigen affinity column.

Accession

P55769

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

NHP2-like protein 1 (SNU13) is a ~14 kDa protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

1. Singh, S. et al. (2021) Science (New York, N.Y.) 373, eabj5338. PMID: 34516797

2. Bertram, K. et al. (2017) Cell 170, 701-713.e11. PMID: 28781166

3. Nottrott, S. et al. (1999) The EMBO journal 18, 6119-33. PMID: 10545122

4. Liu, S. et al. (2007) Science (New York, N.Y.) 316, 115-20. PMID: 17412961

5. Zhang, D. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2406961121. PMID: 39570315

Note

For research use only.

Images

References

Datasheet

Anti-Human SNU13 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SNU13 Polyclonal Antibody (HX240014)

Overview

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References

Datasheet

SDS

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