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Anti-Human LRR1 Polyclonal Antibody (HP210014)

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Overview
Catalog No.HP210014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human LRR1 (Lys135-Gly303).
Target 4-1BBlrr, LRR1, PPIL5, Peptidylprolyl isomerase-like 5, 4-1BB-mediated-signaling molecule, LRR-repeat protein 1, LRR-1, Leucine-rich repeat protein 1
Purification Purified by antigen affinity column.
Accession Q96L50
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Leucine-rich repeat protein 1 (LRR1) is a ~46 kDa protein. Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.

1. Kamura, T. et al. (2004) Genes & development 18, 3055-65. PMID: 15601820
2. Jang, LK. et al. (2001) Molecules and cells 12, 304-12. PMID: 11804328
Note For research use only.
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Formula
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Anti-Human LRR1 Polyclonal Antibody

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