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Anti-Human MCM8 Polyclonal Antibody (HP407014)

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Overview
Catalog No.HP407014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human MCM8 (Ser90-Lys366).
Target MCM8, C20orf154, Minichromosome maintenance 8, DNA helicase MCM8
Purification Purified by antigen affinity column.
Accession Q9UJA3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

DNA helicase MCM8 is a ~93 kDa protein. Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression.

1. Park, J. et al. (2013) Molecular and cellular biology 33, 1632-44. PMID: 23401855
2. McKinzey, DR. et al. (2023) Nucleic acids research 51, 7330-7341. PMID: 37309874
3. Lee, KY. et al. (2015) Nature communications 6, 7744. PMID: 26215093
4. Volkening, M. et al. (2005) Molecular and cellular biology 25, 1560-8. PMID: 15684404
5. Klucnika, A. et al. (2023) The Journal of cell biology 222. PMID: 36355348
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human MCM8 Polyclonal Antibody

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