Anti-Human ZFP36L1 Polyclonal Antibody (HC370014)

Name: Anti-Human ZFP36L1 Polyclonal Antibody
Brand: abinScience
SKU: HC370014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
Images
References
Datasheet

Overview

Catalog No.

HC370014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZFP36L1 (Arg121-Arg195).

Target

ERF-1, ZFP36-like 1, TIS11B, BRF1, ZFP36L1, Butyrate response factor 1, Zinc finger protein 36, C3H1 type-like 1, ERF1, RNF162B, BERG36, TPA-induced sequence 11b, mRNA decay activator protein ZFP36L1, EGF-response factor 1

Purification

Purified by antigen affinity column.

Accession

Q07352

RRID

Anti-Human ZFP36L1 Polyclonal Antibody (abinScience Cat# HC370014, RRID:AB_3731159)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

mRNA decay activator protein ZFP36L1 is a ~36 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail. Binds to 3'-UTR ARE of numerous mRNAs.

1. Stoecklin, G. et al. (2002) The EMBO journal 21, 4709-18. PMID: 12198173

2. Ciais, D. et al. (2004) Oncogene 23, 8673-80. PMID: 15467755

3. Schmidlin, M. et al. (2004) The EMBO journal 23, 4760-9. PMID: 15538381

4. Benjamin, D. et al. (2006) Molecular and cellular biology 26, 9497-507. PMID: 17030608

5. Duan, H. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 497-509. PMID: 19179481

6. Vignudelli, T. et al. (2010) Molecular biology of the cell 21, 3340-51. PMID: 20702587

7. Viengchareun, S. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 2213-21. PMID: 24700863

8. Zekavati, A. et al. (2014) PloS one 9, e102625. PMID: 25014217

9. Adachi, S. et al. (2014) Nucleic acids research 42, 10037-49. PMID: 25106868

10. Chen, MT. et al. (2015) Scientific reports 5, 16229. PMID: 26542173

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human ZFP36L1 polyclonal antibody at 1ug/mL on recombinant Human ZFP36L1 (Catalog No. HC370012).

References

Datasheet

Anti-Human ZFP36L1 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ZFP36L1 Polyclonal Antibody (HC370014)

Overview

Images

References

Datasheet

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