

| Catalog No. | HB122014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human RAC2 (Met1-Leu192). | ||||||||
| Target | Small G protein, GX, p21-Rac2, Ras-related C3 botulinum toxin substrate 2, RAC2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P15153 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Ras-related C3 botulinum toxin substrate 2 (RAC2) is a ~21 kDa protein. Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). 1. Hsu, AP. et al. (2019) Blood 133, 1977-1988. PMID: 30723080 2. Knaus, UG. et al. (1991) Science (New York, N.Y.) 254, 1512-5. PMID: 1660188 | ||||||||
| Note | For research use only. |
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