Anti-Human ASIC2 Polyclonal Antibody (HS947014)

Name: Anti-Human ASIC2 Polyclonal Antibody
Brand: abinScience
SKU: HS947014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HS947014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ASIC2 (Gln71-Lys421).

Target

BNaC1, ACCN, ACCN1, Mammalian degenerin homolog, Acid-sensing ion channel 2, BNAC1, MDEG, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, ASIC2, Brain sodium channel 1, Amiloride-sensitive cation channel neuronal 1, BNC1

Purification

Purified by antigen affinity column.

Accession

Q16515

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Acid-sensing ion channel 2 (ASIC2) is a ~57 kDa protein. Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system. Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize. Highly selective for sodium, they are permeable to other cations. By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction.

1. Babinski, K. et al. (2000) The Journal of biological chemistry 275, 28519-25. PMID: 10842183

2. Diochot, S. et al. (2012) Nature 490, 552-5. PMID: 23034652

3. Price, MP. et al. (1996) The Journal of biological chemistry 271, 7879-82. PMID: 8626462

4. Waldmann, R. et al. (1996) The Journal of biological chemistry 271, 10433-6. PMID: 8631835

Note

For research use only.

Images

References

Datasheet

Anti-Human ASIC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human ASIC2 Polyclonal Antibody (HS947014)

Overview

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References

Datasheet

SDS

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