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Anti-Human USP10 Polyclonal Antibody (HC297014)

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Overview
Catalog No.HC297014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human USP10 (Thr600-Leu798).
Target Ubiquitin thioesterase 10, USP10, Ubiquitin carboxyl-terminal hydrolase 10, Ubiquitin-specific-processing protease 10, Deubiquitinating enzyme 10, KIAA0190
Purification Purified by antigen affinity column.
Accession Q14694
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Ubiquitin carboxyl-terminal hydrolase 10 (USP10) is a ~87 kDa protein. Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13.

1. Soncini, C. et al. (2001) Oncogene 20, 3869-79. PMID: 11439350
2. Boulkroun, S. et al. (2008) American journal of physiology. Renal physiology 295, F889-900. PMID: 18632802
3. Meyer, C. et al. (2020) Molecular cell 77, 1193-1205.e5. PMID: 31981475
4. Yuan, J. et al. (2010) Cell 140, 384-96. PMID: 20096447
5. Liu, J. et al. (2011) Cell 147, 223-34. PMID: 21962518
6. Kedersha, N. et al. (2016) The Journal of cell biology 212, 845-60. PMID: 27022092
9. Sanders, DW. et al. (2020) Cell 181, 306-324.e28. PMID: 32302570
Note For research use only.
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Formula
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Anti-Human USP10 Polyclonal Antibody

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