Anti-Human ZNF143 Polyclonal Antibody (HW561014)

Name: Anti-Human ZNF143 Polyclonal Antibody
Brand: abinScience
SKU: HW561014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HW561014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZNF143 (Gly263-Thr438).

Target

STAF, SPH-binding factor, Selenocysteine tRNA gene transcription-activating factor, Zinc finger protein 143, ZNF143, SBF, hStaf

Purification

Purified by antigen affinity column.

Accession

P52747

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Zinc finger protein 143 (ZNF143) is a ~68 kDa protein. Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function.

1. Kubota, H. et al. (2000) The Journal of biological chemistry 275, 28641-8. PMID: 10893243

2. Grossman, CE. et al. (2004) The Journal of biological chemistry 279, 12190-205. PMID: 14702349

3. Yuan, CC. et al. (2007) Molecular and cellular biology 27, 8729-38. PMID: 17938208

4. Vinckevicius, A. et al. (2015) Molecular and cellular biology 35, 4135-46. PMID: 26416877

5. Narducci, DN. et al. (2025) Molecular cell 85, 9-23.e9. PMID: 39708803

6. Myslinski, E. et al. (1998) The Journal of biological chemistry 273, 21998-2006. PMID: 9705341

7. Rincon, JC. et al. (1998) Nucleic acids research 26, 4846-52. PMID: 9776743

8. Myslinski, E. et al. (2006) The Journal of biological chemistry 281, 39953-62. PMID: 17092945

9. Anno, YN. et al. (2011) Nucleic acids research 39, 3116-27. PMID: 21177654

10. Ngondo-Mbongo, RP. et al. (2013) Nucleic acids research 41, 4000-14. PMID: 23408857

Note

For research use only.

Images

References

Datasheet

Anti-Human ZNF143 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human ZNF143 Polyclonal Antibody (HW561014)

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Datasheet

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