Anti-Human SCN9A Polyclonal Antibody (HS929014)

Name: Anti-Human SCN9A Polyclonal Antibody
Brand: abinScience
SKU: HS929014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HS929014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SCN9A (Glu1761-Lys1918).

Target

Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na

Purification

Purified by antigen affinity column.

Accession

Q15858

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.

1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606

2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069

3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499

4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479

5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487

6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784

7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195

8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203

9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human SCN9A polyclonal antibody at 1ug/mL on recombinant Human SCN9A (Catalog No. HS929012).

References

Datasheet