

| Catalog No. | HB257014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human RAB4A (Asp11-Gly181). | ||||||||
| Target | Ras-related protein Rab-4A, RAB4A, RAB4 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P20338 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Ras-related protein Rab-4A (RAB4A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. 1. Huber, SK. et al. (2005) FEBS letters 579, 2821-9. PMID: 15907487 2. Eathiraj, S. et al. (2005) Nature 436, 415-9. PMID: 16034420 3. Kofler, N. et al. (2018) The Journal of biological chemistry 293, 4805-4817. PMID: 29425100 | ||||||||
| Note | For research use only. |
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