Anti-Human IL19 Polyclonal Antibody (HV492014)

Name: Anti-Human IL19 Polyclonal Antibody
Brand: abinScience
SKU: HV492014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV492014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL19 (Leu25-Ala177).

Target

Melanoma differentiation-associated protein-like protein, Interleukin-19, IL-19, IL19, NG.1, ZMDA1

Purification

Purified by antigen affinity column.

Accession

Q9UHD0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-19 (IL19) is a ~20 kDa protein. Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation. Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3.

1. Small, SH. et al. (2021) Science signaling 14, eaba2611. PMID: 34932373

2. Oral, HB. et al. (2006) European journal of immunology 36, 380-8. PMID: 16365913

3. Parrish-Novak, J. et al. (2002) The Journal of biological chemistry 277, 47517-23. PMID: 12351624

4. Dumoutier, L. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3545-9. PMID: 11564763

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human IL19 polyclonal antibody at 1ug/mL on recombinant Human IL19 (Catalog No. HV492012).

References

Datasheet