Anti-KYAT1 Polyclonal Antibody (HS809014)

Name: Anti-KYAT1 Polyclonal Antibody
Brand: abinScience
SKU: HS809014
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HS809014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human KYAT1 (Met1-Leu372).

Target

KATI, Cysteine-S-conjugate beta-lyase, Glutamine--phenylpyruvate transaminase, Kynurenine--oxoglutarate transaminase 1, Kynurenine--oxoglutarate transaminase I, KYAT1, Kynurenine aminotransferase 1, CCBL1, GTK, Glutamine transaminase K, Kynurenine aminotransferase I

Purification

Purified by antigen affinity column.

Accession

Q16773

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Kynurenine--oxoglutarate transaminase 1 (KYAT1) is a ~47 kDa protein. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.

1. Han, Q. et al. (2009) Journal of medicinal chemistry 52, 2786-93. PMID: 19338303

2. Nadvi, NA. et al. (2017) Protein science : a publication of the Protein Society 26, 727-736. PMID: 28097769

3. Perry, S. et al. (1995) FEBS letters 360, 277-80. PMID: 7883047

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-KYAT1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Raji cell lysate
Lane 2: SW620 cell lysate
Lane 3: Mouse liver lysate
Lane 4: Mouse kidney lysate
Lane 5: Mouse heart lysate