Anti-ABCC3 Polyclonal Antibody (HT036014)

Name: Anti-ABCC3 Polyclonal Antibody
Brand: abinScience
SKU: HT036014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT036014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ABCC3 (Phe1291-Asp1523).

Target

ABCC3, MRP3, MOAT-D, CMOAT2, Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multidrug resistance-associated protein 3, Multi-specific organic anion transporter D, MLP2

Purification

Purified by antigen affinity column.

Accession

O15438

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

ATP-binding cassette sub-family C member 3 (ABCC3/MRP3) is a ~169 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).

1. Kool, M. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 6914-9. PMID: 10359813

2. Zelcer, N. et al. (2001) The Journal of biological chemistry 276, 46400-7. PMID: 11581266

3. Lee, YM. et al. (2004) Pharmacogenetics 14, 213-23. PMID: 15083066

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ABCC3 polyclonal antibody at 1ug/mL on recombinant ABCC3 (Catalog No. HT036012).

References

Datasheet

Anti-ABCC3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ABCC3 Polyclonal Antibody (HT036014)

Overview

Images

References

Datasheet

SDS

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