

| Catalog No. | HV610014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human FBLN5 (Leu99-Cys205). | ||||||||
| Target | UP50, Urine p50 protein, DANCE, Fibulin-5, Developmental arteries and neural crest EGF-like protein, Dance, FBLN5, FIBL-5 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q9UBX5 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Fibulin-5 (FBLN5) is a ~50 kDa protein. Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. 1. Claus, S. et al. (2008) The Journal of investigative dermatology 128, 1442-50. PMID: 18185537 2. Nakamura, T. et al. (1999) The Journal of biological chemistry 274, 22476-83. PMID: 10428823 3. El-Hallous, E. et al. (2007) The Journal of biological chemistry 282, 8935-46. PMID: 17255108 | ||||||||
| Note | For research use only. |
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