Anti-PSMB8 Polyclonal Antibody (HB676014)

Name: Anti-PSMB8 Polyclonal Antibody
Brand: abinScience
SKU: HB676014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB676014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PSMB8 (Thr75-Ser261).

Target

Low molecular mass protein 7, Macropain subunit C13, Really interesting new gene 10 protein, RING10, LMP7, Y2, Proteasome component C13, PSMB5i, Multicatalytic endopeptidase complex subunit C13, Proteasome subunit beta-5i, Proteasome subunit beta type-8, PSMB8

Purification

Purified by antigen affinity column.

Accession

P28062

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Proteasome subunit beta type-8 (PSMB8) is a ~30 kDa protein. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein.

1. Ebstein, F. et al. (2016) Scientific reports 6, 24032. PMID: 27049119

Note

For research use only.

Images

References

Datasheet

Anti-PSMB8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-PSMB8 Polyclonal Antibody (HB676014)

Overview

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References

Datasheet

SDS

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