Anti-DAO Polyclonal Antibody (HB803014)

Name: Anti-DAO Polyclonal Antibody
Brand: abinScience
SKU: HB803014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HB803014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DAO (Met1-Leu347).

Target

DAO, DAMOX, D-amino-acid oxidase, DAAO

Purification

Purified by antigen affinity column.

Accession

P14920

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

D-amino-acid oxidase (DAO) is a ~39 kDa protein. Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients. Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission. Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway. Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor.

1. Molla, G. et al. (2006) FEBS letters 580, 2358-64. PMID: 16616139

2. Kawazoe, T. et al. (2006) Protein science : a publication of the Protein Society 15, 2708-17. PMID: 17088322

3. Kawazoe, T. et al. (2007) Biochemical and biophysical research communications 355, 385-91. PMID: 17303072

4. Sacchi, S. et al. (2008) The Journal of biological chemistry 283, 22244-56. PMID: 18544534

5. Mitchell, J. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 7556-61. PMID: 20368421

6. Katane, M. et al. (2011) Amino acids 40, 467-76. PMID: 20567862

7. Katane, M. et al. (2010) Biochimie 92, 1371-8. PMID: 20603179

8. Sasabe, J. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 627-32. PMID: 22203986

9. Caldinelli, L. et al. (2013) Biochimica et biophysica acta 1832, 400-10. PMID: 23219954

10. Katane, M. et al. (2013) Journal of medicinal chemistry 56, 1894-907. PMID: 23391306

Note

For research use only.

Images

References

Datasheet

Anti-DAO Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-DAO Polyclonal Antibody (HB803014)

Overview

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Datasheet

SDS

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