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Anti-TNS3 Polyclonal Antibody (HP907014)

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Overview
Catalog No.HP907014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human TNS3 (Met1-Val242).
Target Tumor endothelial marker 6, TPP, Tensin-like SH2 domain-containing protein 1, Tensin-3, TNS3, TENS1, TEM6
Purification Purified by antigen affinity column.
Accession Q68CZ2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Tensin-3 (TNS3) is a ~155 kDa protein. May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1.

1. Katz, M. et al. (2007) Nature cell biology 9, 961-9. PMID: 17643115
2. Shih, YP. et al. (2015) Biochimica et biophysica acta 1853, 3258-65. PMID: 26427649
3. Cao, X. et al. (2015) Nature communications 6, 7721. PMID: 26166433
4. Zuidema, A. et al. (2022) The Journal of cell biology 221. PMID: 35687021
5. Park, GC. et al. (2019) Cells 9. PMID: 31905841
Note For research use only.
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Formula
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V₁ (Stock Vol.)
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Anti-TNS3 Polyclonal Antibody

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