Anti-TNKS2 Polyclonal Antibody (HV525014)

Name: Anti-TNKS2 Polyclonal Antibody
Brand: abinScience
SKU: HV525014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV525014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TNKS2 (Ser959-Gly1166).

Target

TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2

Purification

Purified by antigen affinity column.

Accession

Q9H2K2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a ~126 kDa protein. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.

1. Cook, BD. et al. (2002) Molecular and cellular biology 22, 332-42. PMID: 11739745

2. Sbodio, JI. et al. (2002) The Biochemical journal 361, 451-9. PMID: 11802774

3. Huang, SM. et al. (2009) Nature 461, 614-20. PMID: 19759537

4. Zhang, Y. et al. (2011) Nature cell biology 13, 623-9. PMID: 21478859

5. Cho-Park, PF. et al. (2013) Cell 153, 614-27. PMID: 23622245

6. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379

Note

For research use only.

Images

References

Datasheet

Anti-TNKS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-TNKS2 Polyclonal Antibody (HV525014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us