Anti-Human GPR37 Polyclonal Antibody (HT211014)

Name: Anti-Human GPR37 Polyclonal Antibody
Brand: abinScience
SKU: HT211014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HT211014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human GPR37 (Arg401-Leu443).

Target

Endothelin B receptor-like protein 1, G-protein coupled receptor 37, Prosaposin receptor GPR37, Parkin-associated endothelin receptor-like receptor, GPR37, PAELR, ETBR-LP-1

Purification

Purified by antigen affinity column.

Accession

O15354

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Prosaposin receptor GPR37 is a ~67 kDa protein. G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation. Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway.

1. Imai, Y. et al. (2001) Cell 105, 891-902. PMID: 11439185

2. Meyer, RC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 9529-34. PMID: 23690594

3. Berger, BS. et al. (2017) EMBO reports 18, 712-725. PMID: 28341812

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-GPR37 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: 293T cell lysate
Lane 3: Mouse brain lysate
Lane 4: Rat brain lysate

References

Datasheet

Anti-Human GPR37 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-Human GPR37 Polyclonal Antibody (HT211014)

Overview

Images

References

Datasheet

SDS

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