Anti-GREM1 Polyclonal Antibody (HT246014)

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Datasheet

Overview

Catalog No.

HT246014

Description

Anti-GREM1 Polyclonal Antibody (HT246014) is a rabbit polyclonal antibody detecting GREM1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Macaca mulatta.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat, Chicken, Macaca mulatta, Xenopus laevis

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GREM1 (Lys26-Asp184).

Target

Cysteine knot superfamily 1, BMP antagonist 1, CKTSF1B1, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, DRM, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, DAND2

Purification

Purified by antigen affinity column.

Accession

O60565

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gremlin-1 (GREM1/DAND2) is a ~20 kDa protein. Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.

1. Kišonaitė, M. et al. (2016) The Biochemical journal 473, 1593-604. PMID: 27036124

Note

For research use only.

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