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Anti-Human HBS1L Polyclonal Antibody (HP453014)

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Overview
Catalog No.HP453014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human HBS1L (Gly257-Lys478).
Target HBS1L, KIAA1038, ERFS, HBS1, HBS1-like protein
Purification Purified by antigen affinity column.
Accession Q9Y450
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

HBS1-like protein (HBS1L) is a ~75 kDa protein. GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.

1. Pisareva, VP. et al. (2011) The EMBO journal 30, 1804-17. PMID: 21448132
2. Saito, S. et al. (2013) The Journal of biological chemistry 288, 17832-43. PMID: 23667253
3. Shao, S. et al. (2016) Cell 167, 1229-1240.e15. PMID: 27863242
4. Zinoviev, A. et al. (2020) Molecular cell 77, 1340-1349.e6. PMID: 32006463
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human HBS1L Polyclonal Antibody

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