Anti-Mouse NDP/Norrin Polyclonal Antibody (MX134014)

Name: Anti-Mouse NDP/Norrin Polyclonal Antibody
Brand: abinScience
SKU: MX134014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
Images
References
Datasheet

Overview

Catalog No.

MX134014

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse NDP/Norrin (Arg36-Ser131).

Target

Norrin (Norrie disease protein homolog)

Purification

Purified by antigen affinity column.

Accession

P48744

RRID

Anti-Mouse NDP/Norrin Polyclonal Antibody (abinScience Cat# MX134014, RRID:AB_3723533)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Norrin (NDP) is a ~14 kDa protein. Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse NDP/Norrin polyclonal antibody at 1ug/mL on recombinant Mouse NDP/Norrin (Catalog No. MX134012).

References

Datasheet

Anti-Mouse NDP/Norrin Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse NDP/Norrin Polyclonal Antibody (MX134014)

Overview

Images

References

Datasheet

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