Anti-Mouse IL1RL1/ST2 Polyclonal Antibody (MX139014)

Name: Anti-Mouse IL1RL1/ST2 Polyclonal Antibody
Brand: abinScience
SKU: MX139014
Price: 96 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

20ug
50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

MX139014

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse IL1RL1/ST2 (Ser27-Arg332).

Target

Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)

Purification

Purified by antigen affinity column.

Accession

P14719

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~64 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

1. Chackerian, AA. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 2551-5. PMID: 17675517

2. Palmer, G. et al. (2008) Cytokine 42, 358-64. PMID: 18450470

3. Zhao, J. et al. (2012) Nature immunology 13, 651-8. PMID: 22660580

4. Osbourn, M. et al. (2017) Immunity 47, 739-751.e5. PMID: 29045903

5. Faas, M. et al. (2021) Immunity 54, 2531-2546.e5. PMID: 34644537

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-IL1RL1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: SGC-7901 cell lysate
Lane 3: HUVEC cell lysate
Lane 4: HepG2 cell lysate
Lane 5: Mouse brain lysate

References

Datasheet

Anti-Mouse IL1RL1/ST2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse IL1RL1/ST2 Polyclonal Antibody (MX139014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us