Anti-SLC17A5 Polyclonal Antibody (HV722014)

Name: Anti-SLC17A5 Polyclonal Antibody
Brand: abinScience
SKU: HV722014
Price: 96 USD
Availability: InStock

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SDS

Overview

Catalog No.

HV722014

Description

Anti-SLC17A5 Polyclonal Antibody (HV722014) is a rabbit polyclonal antibody detecting SLC17A5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SLC17A5 (Val65-Gln108).

Target

H(+)/sialic acid cotransporter, H(+)/nitrate cotransporter, Sialin, AST, Vesicular H(+)/Aspartate-glutamate cotransporter, SLC17A5, Membrane glycoprotein HP59, Solute carrier family 17 member 5

Purification

Purified by antigen affinity column.

Accession

Q9NRA2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sialin (SLC17A5) is a ~54 kDa protein. Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1.

1. Morin, P. et al. (2004) The EMBO journal 23, 4560-70. PMID: 15510212

2. Miyaji, T. et al. (2011) Journal of neurochemistry 119, 1-5. PMID: 21781115

3. Qin, L. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 13434-9. PMID: 22778404

4. Lodder-Gadaczek, J. et al. (2013) The Biochemical journal 454, 31-8. PMID: 23889254

Note

For research use only.

Images

References

Datasheet

Anti-SLC17A5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SLC17A5 Polyclonal Antibody (HV722014)

Overview

Images

References

Datasheet

SDS

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