Anti-Human KAT2B Polyclonal Antibody (HA390014)

Name: Anti-Human KAT2B Polyclonal Antibody
Brand: abinScience
SKU: HA390014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HA390014

Description

Anti-Human KAT2B Polyclonal Antibody (HA390014) is a rabbit polyclonal antibody detecting KAT2B in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KAT2B (Leu352-Lys832).

Target

P300/CBP-associated factor, P/CAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, Spermidine acetyltransferase KAT2B, PCAF, Histone acetyltransferase KAT2B, KAT2B, Histone acetyltransferase PCAF

Purification

Purified by antigen affinity column.

Accession

Q92831

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Histone acetyltransferase KAT2B is a ~93 kDa protein. Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A.

1. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521

2. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905

3. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335

4. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180

5. Lin, R. et al. (2013) Molecular cell 51, 506-518. PMID: 23932781

6. Chen, S. et al. (2016) Nature communications 7, 10734. PMID: 26867678

7. Fournier, M. et al. (2016) Nature communications 7, 13227. PMID: 27796307

8. Ghosh, TK. et al. (2018) Journal of molecular and cellular cardiology 114, 185-198. PMID: 29174768

9. Zhang, W. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9855-60. PMID: 9707565

Note

For research use only.

Images

References

Datasheet

Anti-Human KAT2B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human KAT2B Polyclonal Antibody (HA390014)

Overview

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References

Datasheet

SDS

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