Anti-Human CD367/CLEC4A Polyclonal Antibody (HV145014)

Name: Anti-Human CD367/CLEC4A Polyclonal Antibody
Brand: abinScience
SKU: HV145014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV145014

Description

Anti-Human CD367/CLEC4A Polyclonal Antibody (HV145014) is a rabbit polyclonal antibody detecting CLEC4A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD367/CLEC4A (Gln70-Leu237).

Target

C-type lectin domain family 4 member A, C-type lectin DDB27, C-type lectin superfamily member 6, Dendritic cell immunoreceptor, Lectin-like immunoreceptor, CD367, CLEC4A, CLECSF6, DCIR, LLIR, HDCGC13P

Purification

Purified by antigen affinity column.

Accession

Q9UMR7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-type lectin domain family 4 member A (CD367/CLEC4A) is a ~27 kDa protein. C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production.

1. Nagae, M. et al. (2016) FEBS letters 590, 1280-8. PMID: 27015765

2. Bates, EE. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1973-83. PMID: 10438934

3. Meyer-Wentrup, F. et al. (2008) Blood 111, 4245-53. PMID: 18258799

4. Klechevsky, E. et al. (2010) Blood 116, 1685-97. PMID: 20530286

Note

For research use only.

Images

References

Datasheet

Anti-Human CD367/CLEC4A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CD367/CLEC4A Polyclonal Antibody (HV145014)

Overview

Images

References

Datasheet

SDS

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