Anti-Human TARBP2 Polyclonal Antibody (HS711014)

Name: Anti-Human TARBP2 Polyclonal Antibody
Brand: abinScience
SKU: HS711014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HS711014

Description

Anti-Human TARBP2 Polyclonal Antibody (HS711014) is a rabbit polyclonal antibody detecting TARBP2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TARBP2 (Thr264-Lys366).

Target

RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2, TRBP

Purification

Purified by antigen affinity column.

Accession

Q15633

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

RISC-loading complex subunit TARBP2 is a ~39 kDa protein. Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.

1. Chendrimada, TP. et al. (2005) Nature 436, 740-4. PMID: 15973356

2. Haase, AD. et al. (2005) EMBO reports 6, 961-7. PMID: 16142218

3. Gregory, RI. et al. (2005) Cell 123, 631-40. PMID: 16271387

4. Maniataki, E. et al. (2005) Genes & development 19, 2979-90. PMID: 16357216

5. Lee, Y. et al. (2006) The EMBO journal 25, 522-32. PMID: 16424907

6. Kok, KH. et al. (2007) The Journal of biological chemistry 282, 17649-57. PMID: 17452327

7. MacRae, IJ. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 512-7. PMID: 18178619

8. Fukunaga, R. et al. (2012) Cell 151, 533-46. PMID: 23063653

9. Ling, T. et al. (2019) Molecular immunology 109, 116-125. PMID: 30927622

Note

For research use only.

Images

References

Datasheet

Anti-Human TARBP2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TARBP2 Polyclonal Antibody (HS711014)

Overview

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References

Datasheet

SDS

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