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Anti-Human IL4I1 Polyclonal Antibody (HP675014)

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Overview
Catalog No.HP675014
Description
Anti-Human IL4I1 Polyclonal Antibody (HP675014) is a rabbit polyclonal antibody detecting IL4I1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human IL4I1 (Gln22-Asn505).
Target L-amino-acid oxidase, LAAO, LAO, 1.4.3.2, 1.4.3.25, Interleukin-4-induced protein 1, IL4-induced protein 1, hIL4I1, Protein Fig-1, hFIG1, IL4I1, FIG1, UNQ636/PRO1265
Purification Purified by antigen affinity column.
Accession Q96RQ9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

L-amino-acid oxidase (IL4I1) is a ~62 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer.

1. Boulland, ML. et al. (2007) Blood 110, 220-7. PMID: 17356132
2. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467
3. Zhang, X. et al. (2020) Journal of agricultural and food chemistry 68, 10678-10684. PMID: 32866000
4. Molinier-Frenkel, V. et al. (2016) Genes and immunity 17, 148-52. PMID: 26673964
6. Cousin, C. et al. (2015) European journal of immunology 45, 1772-82. PMID: 25778793
Note For research use only.
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Datasheet
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Formula
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Anti-Human IL4I1 Polyclonal Antibody

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