

| Catalog No. | HA838014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human FAF2 Polyclonal Antibody (HA838014) is a rabbit polyclonal antibody detecting FAF2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human FAF2 (Arg122-Gln254). | ||||||||
| Target | FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8, FAF2, ETEA, KIAA0887, UBXD8, UBXN3B | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q96CS3 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | FAS-associated factor 2 (FAF2) is a ~52 kDa protein. Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. 1. Mueller, B. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12325-30. PMID: 18711132 2. Xia, Y. et al. (2014) Journal of neurochemistry 129, 99-106. PMID: 24215460 3. Osorio, FG. et al. (2016) Nature medicine 22, 91-6. PMID: 26692333 4. Olzmann, JA. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 1345-50. PMID: 23297223 5. Gwon, Y. et al. (2021) Science (New York, N.Y.) 372, eabf6548. PMID: 34739333 | ||||||||
| Note | For research use only. |
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