

| Catalog No. | MB984014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse CD9 Polyclonal Antibody (MB984014) is a rabbit polyclonal antibody detecting CD9 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse CD9 (Thr110-Ile193). | ||||||||
| Target | CD9 antigen, CD9, Cd9 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P40240 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | CD9 antigen is a ~25 kDa protein. Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. 1. Le Naour, F. et al. (2000) Science (New York, N.Y.) 287, 319-21. PMID: 10634790 2. Miyado, K. et al. (2000) Science (New York, N.Y.) 287, 321-4. PMID: 10634791 3. Kaji, K. et al. (2000) Nature genetics 24, 279-82. PMID: 10700183 4. Ishibashi, T. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 96-102. PMID: 14715942 5. Jégou, A. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 10946-51. PMID: 21690351 6. Charrin, S. et al. (2013) Nature communications 4, 1674. PMID: 23575678 7. Takeda, Y. et al. (2003) The Journal of cell biology 161, 945-56. PMID: 12796480 9. Takeda, Y. et al. (2008) The Journal of biological chemistry 283, 26089-97. PMID: 18662991 | ||||||||
| Note | For research use only. |



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