Anti-Human CDC5L Polyclonal Antibody (HA841014)

Name: Anti-Human CDC5L Polyclonal Antibody
Brand: abinScience
SKU: HA841014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA841014

Description

Anti-Human CDC5L Polyclonal Antibody (HA841014) is a rabbit polyclonal antibody detecting CDC5L in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human CDC5L (Ser591-Glu851).

Target

CDC5L, PCDC5RP, KIAA0432, Cdc5-like protein, Cell division cycle 5-like protein, Pombe cdc5-related protein

Purification

Purified by antigen affinity column.

Accession

Q99459

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cell division cycle 5-like protein (CDC5L) is a ~92 kDa protein. DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

1. Jurica, MS. et al. (2002) RNA (New York, N.Y.) 8, 426-39. PMID: 11991638

2. Grote, M. et al. (2010) Molecular and cellular biology 30, 2105-19. PMID: 20176811

3. Bertram, K. et al. (2017) Nature 542, 318-323. PMID: 28076346

4. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770

5. Zhan, X. et al. (2018) Science (New York, N.Y.) 359, 537-545. PMID: 29301961

6. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106

7. Haselbach, D. et al. (2018) Cell 172, 454-464.e11. PMID: 29361316

8. Fica, SM. et al. (2019) Science (New York, N.Y.) 363, 710-714. PMID: 30705154

9. Zhang, X. et al. (2019) Cell research 29, 274-285. PMID: 30728453

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-KANK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse lung lysate

References

Datasheet

Anti-Human CDC5L Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human CDC5L Polyclonal Antibody (HA841014)

Overview

Images

References

Datasheet

SDS

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